| Tue 04 May | Douglas A | v | Castletown B |
| Thurs 06 May | Finch Hill B | v | Douglas A |
| Tues 11 May | Douglas A | v | Port Erin A |
| Friday 14 May | Peel Sunset C | v | Douglas A |
| Tues 18 May | Douglas A | v | South Ramsey B |
| Thurs 20 May | Port St Mary A | v | Douglas A |
| Tues 25 May | Douglas A | v | Ballaugh B |
| Thurs 27 May | Nobles A | v | Douglas A |
| Tues 01 June | Douglas A | v | Onchan A |
| Thurs 03 June | North Ramsey A | v | Douglas A |
| Tues 08 June | Peel Sunset B | v | Douglas A |
| Thurs 10 June | Castletown B | v | Douglas A |
| Tues 15 June | Douglas A | v | Finch Hill B |
| Thurs 17 June | Port Erin A | v | Douglas A |
| Tues 22 June | Douglas A | v | Peel Sunset C |
| Thurs 24 June | South Ramsey B | v | Douglas A |
| Tues 29 June | Douglas A | v | Port St Mary A |
| Thurs 01 July | Ballaugh B | v | Douglas A |
| Tues 13 July | Douglas A | v | Nobles A |
| Tues 20 July | Onchan A | v | Douglas A |
| Tues 03 Aug | Douglas A | v | North Ramsey A |
| Thurs 05 Aug | Douglas A | v | Peel Sunset B |
Ladies’ team fixtures 2021